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Nitric oxide inhibits neointimal hyperplasia following vascular injury via differential, cell-specific modulation of SOD-1 in the arterial wall.
Bahnson ES, Koo N, Cantu-Medellin N, Tsui AY, Havelka GE, Vercammen JM, Jiang Q, Kelley EE, Kibbe MR. Nitric Oxide. 2015 Jan 30;44:8-17. PMID: 25460325. PMCID: PMC4304904.

Development and validation of 4 different rat models of uncontrolled hemorrhage.
Morgan CE, Prakash VS, Vercammen JM, Pritts T, Kibbe MR. JAMA Surg. 2015 Apr;150(4):316-24. PMID: 25693160.

Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures.
Moyer TJ, Kassam HA, Bahnson ES, Morgan CE, Tantakitti F, Chew TL, Kibbe MR, Stupp SI. Small. 2015 Jun;11(23):2750-5. PMID: 25649528. PMCID: PMC4478239.

Nitric oxide affects UbcH10 levels differently in type 1 and type 2 diabetic rats.
Rodriguez MP, Tsihlis ND, Emond ZM, Wang Z, Varu VN, Jiang Q, Vercammen JM, Kibbe MR. J Surg Res. 2015 Jun 1;196(1):180-9. PMID: 25801975. PMCID: PMC4430355.

Dawn of a new decade for JAMA Surgery.
Kibbe MR. JAMA Surg. 2015 Jan;150(1):7-8. PMID: 25565578.

Sex-based differential regulation of oxidative stress in the vasculature by nitric oxide.
Morales RC, Bahnson ES, Havelka GE, Cantu-Medellin N, Kelley EE, Kibbe MR. Redox Biol. 2015;4:226-33. PMID: 25617803.

Periadventitial atRA citrate-based polyester membranes reduce neointimal hyperplasia and restenosis after carotid injury in rats.
Gregory EK, Webb AR, Vercammen JM, Flynn ME, Ameer GA, Kibbe MR. Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1419-29. PMID: 25239800. PMCID: PMC4233299.

Engineering biodegradable polyester elastomers with antioxidant properties to attenuate oxidative stress in tissues.
van Lith R,Gregory EK, Yang J, Kibbe MR, Ameer GA. Biomaterials. 2014 Sep;35:8113-22. PMID: 24976244.

The art and science of publishing: reflections from editors of surgery journals.
Kibbe MR, Sarr MG, Livingston EH, Freischlag JA, Lillemoe KD, McFadden DW. J Surg Res. 2014 Jan;186(1):7-15. PMID: 24035228.

Role of metabolic environment on nitric oxide mediated inhibition of neointimal hyperplasia in type 1 and type 2 diabetes.
Rodriguez MP, Emond ZM, Wang Z, Martinez J, Jiang Q, Kibbe MR. Nitric Oxide. 2014 Jan;36:67-75. PMCID: PMC3917719.

Nitric oxide is less effective at inhibiting neointimal hyperplasia in spontaneously hypertensive rats.
Tsihlis ND, Vavra AK, Martinez J, Lee VR, Kibbe MR. Nitric Oxide. 2013 Nov;35:165-74. PMID: 24149190. PMCID: PMC3877576.

Nitric oxide differentially affects ERK and Akt in type 1 and type 2 diabetic rats.
Rodriguez MP, Emond ZM, Varun VN, Ahanchi SS, Martinez J, Kibbe MR. J Surg Res. 2013 Aug;183(2):944-51. PMID:23608617.

Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature.
Tsihlis ND, Kapadia MR, Vavra AK, Flannery WD, Oustwani CS, Jiang Q, Kibbe MR. J Vasc Surg. 2013 Jul;58(1):179-86. PMID: 23375434. PMCID: PMC3696405.

Photo-crosslinked biodegradable elastomers for controlled nitric oxide delivery.
Wang Y, Kibbe MR, Ameer GA. Biomater Sci. 2013 Jun;1(6):625-32. PMID: 24707352. PMCID: PMC3972038.

Nitric oxide delivery via a permeable balloon catheter inhibits neointimal growth after arterial injury.
Havelka GE, Moreira ES, Rodriguez MP, Tsihlis ND, Wang Z, Martinez J, Hrabie JA, Keefer LK, Kibbe MR. J Surg Res. 2013 Mar;180(1):35-42. PMID: 23164361. PMCID:PMC3578007.

How to write a paper.
Kibbe MR. ANZ J Surg. 2013 Jan;83(1-2):90-2. PMID: 23350980.

Nitric oxide decreases activity and levels of the 11S proteasome activator PA28 in the vasculature.
Tsihlis ND, Kapadia MR, Vavra AK, Jiang Q, Fu B, Martinez J, Kibbe MR. Nitric Oxide. 2012 Jun;27(1):50-8. PMID: 22561112.

The role of estrogen receptor a and b in regulating vascular smooth muscle cell proliferation is based on sex.
Hogg ME, Vavra AK, Banerjee MN, Martinez J, Jiang Q, Keefer LK, Chambon P, Kibbe MR. J Surg Res. 2012 Mar;173(1):e1-10. PMID: 22099601. PMCID: PMC3286876.

Antioxidants modulate the antiproliferative effects of nitric oxide on vascular smooth muscle cells and adventitial fibroblasts by regulating oxidative stress.
Gregory EK, Vavra AK, Moreira ES, Havelka GE, Jian Q, Lee VR, Van Lith R, Ameer GA, Kibbe MR. Am J Surg. 2011 Nov;202(5):536-40. PMID: 21944289. PMCID: PMC3216467.

Adventitial contributions of the ERK and Akt pathways to neointimal hyperplasia.
Havelka GE, Hogg ME, Martinez J, Banerjee MN, Jiang Q, Kibbe MR. Am J Surg. 2011 Nov;202(5):515-9. PMID: 21906720. PMCID: PMC3199313.

Nitric oxide increases lysine 48-linked ubiquitination following arterial injury.
Oustwani CS, Tsihlis ND, Vavra AK, Jiang Q, Martinez J, Kibbe MR. J Surg Res. 2011 Sep;170(1):e169-77. PMID: 21737094. PMCID: PMC3154506.

Insights into the effect of nitric oxide and its metabolites nitrite and nitrate at inhibiting neointimal hyperplasia.
Vavra AK, MD; Havelka GE, Martinez J; Lee VR, Fu B; Jiang Q, Keefer LK, Kibbe MR. Nitric Oxide. 2011 Jun;25(1):22-30. PMID: 21554972. PMCID: PMC3119546.

Nitric oxide inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia by increasing the ubiquitination and degradation of UbcH10.
Tsihlis ND, Oustwani CS, Vavra AK, Jiang Q, Keefer LK, Kibbe MR. Cell Biochem Biophys. 2011 Jun;60(1-2):89-97. PMID: 21448667.

Effect of nitric oxide on neointimal hyperplasia based on sex and hormone status.
Hogg ME, Varu VN, Vavra AK, Popowich DA, Banerjee MN, Martinez J, Jiang Q, Saavedra JE Keefer LK, Kibbe MR. Free Radical Biol Med. 2011 May;50(9):1065-74. PMID: 21256959. PMCID: PMC3070831.

Poly(diol-co-citrate)s as novel elastomeric perivascular wraps for the reduction of neointimal hyperplasia.
Serrano MC, Vavra AK, Jen M, Hogg ME, Murar J, Martinez J, Keefer LK, Ameer GA, Kibbe MR. Macromol Biosci. 2011 May;11(5):700-9. PMID: 21341372.

Insulin enhances the effect of nitric oxide at inhibiting neointimal hyperplasia in a rat model of type 1 diabetes.
Varu VN, Ahanchi SS, Hogg ME, Bhikhapurwala HA, Chen A, Popowich DA, Vavra AK, Martinez J, Jiang Q, Saavedra JE, Hrabie JA, Keefer LK, Kibbe MR. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H772-9. PMID: 20562340. PMCID: PMC2944486.

Regulation of reactive oxygen species by p53: implications for nitric oxide mediated apoptosis.
Popowich DA, Aalami OO, Walsh CP, Rossi NB, Bhikhapurwala HA, Jiang Q, Kibbe MR. Am J Physiol: Heart Circ Physiol. 2010 Jun;298(6):H2192-200. PMID: 20382856. PMCID: PMC2886652.

Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury.
Tsihlis ND, Murar J, Kapadia MR, Ahanchi SS, Martinez J, Jiang Q, Saavedra JE, Keefer LK, Kibbe MR. J Vasc Surg. 2010 May;51(5):1248-59. PMID: 20223627. PMCID: PMC2860688.

Biodegradable nitric oxide-releasing poly(diol citrate) elastomers.
Zhao H, Serrano MC, Popowich D, Kibbe MR, Ameer GA. J Biomed Mater Res A. 2010 Apr;93(1):356-63. PMID: 19569216.

Citric acid-based elastomers provide a biocompatible interface for vascular grafts.
Kibbe MR, Martinez J, Popowich DA, Kapadia MR, Ahanchi SS, Aalami OO, Jiang Q, Webb AR, Yang J, Carroll T, Ameer GA. J Biomed Mater Res A. 2010 Apr; 93(1):314-24. PMID: 19569210.

Nitric oxide regulates the 26S proteasome in vascular smooth muscle cells.
Kapadia MR, Eng JW, Jiang Q, Stoyanovsky DA, Kibbe MR. Nitric Oxide. 2009 Jun; 20(4):279-88. PMID: 19233305.

Heightened efficacy of nitric oxide-based therapies in type II diabetes mellitus and metabolic syndrome.
Ahanchi SS, Varu VN, Tsihlis ND, Martinez J, Pearce CG, Kapadia MR, Jiang Q, Saavedra JE, Keefer LK, Hrabie JA, Kibbe, MR. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6): H2388-98. PMID: 18931034. PMCID: PMC2614532.

A reproducible porcine ePTFE arterial bypass model for neointimal hyperplasia.
Kapadia MR, Aalami OO, Najjar SF, Jiang Q, Murar J, Lyle B, Eng J, Kane B, Carroll T, Cahill PM, Kibbe MR. J Surg Res. 2008 Aug; 148(2): 230-237. PMID: 18028957.

Modified prosthetic vascular conduits.
Kapadia MR, Popowich DA, Kibbe MR. Circulation. 2008 Apr;117:1873-1882. PMID: 18391121.

Protective effect of p53 in vascular smooth muscle cells against nitric oxide-induced apoptosis is mediated by up-regulation of heme oxygenase-2.
Kim YM, Choi BM, Kim YS, Kwon YG, Kibbe MR, Billiar TR, Tzeng E. BMB Rep. 2008 Feb;41(2):164-169. PMID: 18315954.

Nitric oxide and nanotechnology: a novel approach to inhibit neointimal hyperplasia.
Kapadia MR, Chow LW, Tsihlis ND, Ahanchi SS, Eng J, Murar J, Martinez J, Popowich DA, Jiang Q, Hrabie JA, Saavedra JE, Keefer LK, Hulvat JF, Stupp SI, and Kibbe MR. J Vasc Surg. 2008 Jan;47:173-82. PMID: 18178471. PMCID: PMC2268106.

Beneficial effect of a short-acting NO donor for the prevention of neointimal hyperplasia.
Pearce CG, Najjar SF, Kapadia MR, Murar J, Eng J, Lyle B, Aalami O, Jiang Q, Hrabie JA, Saavedra JE, Keefer LK, and Kibbe MR. Free Radical Biol Med. 2008 Jan;44:73-81. PMID: 18045549. PMCID: 2174838.

The role of nitric oxide in the pathophysiology of intimal hyperplasia.
Ahanchi SS, Tsihlis ND, and Kibbe MR. J Vasc Surg. 2007 Jun;45:64A-73A. PMID: 17544026.

Nitric oxide-releasing fabrics and other acrylonitrile-based diazeniumdiolates.
DeRosa F, Kibbe MR, Najjar SF, Citro ML, Keefer LK, and Hrabie JA. J Am Chem Soc. 2007 Apr;129(13):3786-7. PMID: 17343382.

Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers.
Yang J, Motlagh D, Allen JB, Webb AR, Kibbe MR, Aalami O, Kapadia M, Carroll TJ, Ameer GA. Adv Mater. 2006 Jun; 18: 1493-8.

Adenovirus-mediated nitric oxide synthase gene transfer.
Raman KG, Shapiro RA, Tzeng E, Kibbe MR. Methods Mol Biol. 2004; 279:225-34. PMID: 15199249.

Local adenoviral-mediated inducible nitric oxide synthase (iNOS) gene transfer inhibits neointimal formation in the porcine coronary stented model.
Wang K, Kessler PD, Zhou Z, Penn MS, Forudi F, Zhou X, Tarakii K, Kibbe MR, Kovesdi I, Brough DE, Topol EJ, Lincoff AM. Molecular Therapy 2003 May;7(5 Pt 1):597-603. PMID: 12718902.

Regulation of tissue factor expression in smooth muscle cells with nitric oxide.
Kibbe MR, Johnnides C, Gleixner SL, Kovesdi I, Lizonova A, Zuckerbraun B, Billiar TR, Tzeng E, and Muluk S. J Vasc Surg 2003 Mar;37:650-659. PMID: 12618706.

Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells.
Kibbe MR, Li J, Nie S, Choi BM, Kovesdi I, Lizonova A, Billiar TR, and Tzeng E. Am J Physiol. 2002 Mar; 282(3):C625-34. PMID: 11832348.

Adenovirus-mediated transfer and expression of b-Gal in injured hippocampus after traumatic brain injury in mice.
Kochanek PM, Janesko KL, Jenkins LW, Yan HQ, Kibbe MR, Robichaud P, Wooditch AC, Clark RS, Dixon CE, Marion DW, and Billiar TR. J Neurotrauma. 2001 Jan;18(1):73-82. PMID: 11200251.

Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia.
Kibbe MR, Tzeng E, Gleixner SL, Watkins SC, Kovesdi I, Lizonova A, Makaroun MS, Billiar TR, and Rhee RY. J Vasc Surg. 2001 Jul; 34(1):156-65. PMID: 11436090.

Nitric oxide induces angiogenesis and upregulates avb3 integrin expression on endothelial cells.
Lee PC, Kibbe MR, Schuchert MJ, Stolz DB, Watkins SC, Griffith BP, Billiar TR, Shears LL 2nd. Microvasc Res. 2000 Nov;60(3):269-280. PMID: 11078643.

Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression.
Villavicencio RT, Liu S, Kibbe MR, Williams DL, Ganster RW, Dyer KF, Tweardy DJ, Billiar TR, Pitt BR. Shock. 2000 Jun; 13(6):441-5. PMID: 10847630.

Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate.
Kibbe MR, Li J, Nie S, Watkins SC, Lizonova A, Kovesdi I, Simmons RL, Billiar T, Tzeng E. J Vasc Surg. 2000 Jun; 31(6):1214-28. PMID: 10842159.

Gene therapy for restenosis.
Kibbe MR, Billiar TR, Tzeng E. Circ Res. 2000 Apr; 86(8):829-33. PMID: 10785503.

Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors.
Kibbe MR, Murdock A, Wickham T, Lizonova A, Kovesdi I, Nie S, Shears L, Billiar T, Tzeng E. Arch Surg. 2000 Feb; 135(2):191-7. PMID: 10668880.

Nitric oxide prevents p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells.
Kibbe MR, Nie S, Seol DW, Kovesdi I, Lizonova A, Makaroun M, Billiar TR, Edith T. J Vasc Surg. 2000 Feb; 31(2):364-74. PMID: 10664504.

Inducible nitric oxide synthase and vascular injury.
Kibbe M, Billiar T, Tzeng E. Cardiovasc Res. 1999 Aug; 43(3):650-7. PMID: 10690336.

Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts.
Kibbe MR, Nie S, Yoneyama T, Hatakeyama K, Lizonova A, Kovesdi I, Billiar TR, Tzeng E. Surgery. 1999 Aug; 126(2):323-9. PMID: 10455901.

Gene therapy and vascular disease.
Kibbe MR, Billiar TR, Tzeng E. Adv Pharm. 1999; 46:85-150. PMID: 10332502.

Nitric oxide synthase gene transfer to the vessel wall.
Kibbe MR, Billiar TR, Tzeng E. Curr Opin Nephrol Hypertens. 1999 Jan; 8(1):75-81. PMID: 9914863.

Adenovirus-mediated gene transfer to liver grafts: an improved method to maximize infectivity.
Chia SH, Geller DA, Kibbe MR, Watkins SC, Fung JJ, Starzl TE, Murase N. Transplantation. 1998 Dec; 66(11):1545-51. PMID: 9869098. PMCID: PMC2955286.

Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo.
Shears LL 2nd, Kibbe MR, Murdock AD, Billiar TR, Lizonova A, Kovesdi I, Watkins SC, Tzeng E. J Am Coll Surg. 1998 Sep; 187(3):295-306. PMID: 9740187.

Our lab puts a strong emphasis on quality publications and provides internal support to improve the quality of our manuscripts. All of us have published our work in high impact, peer-reviewed journals such as: Free Radical Biology and Medicine, Nitric Oxide - Biology and Chemistry, Small, the Journal of the American Chemical Society, the American Journal of Physiology - Heart and Circulatory Physiology, Annals of Vascular Surgery, etc.